This analysis examines the economic impact of an outbreak of highly pathogenic avian influenza (HPAI) and the consequences of regionalization. The results suggest that an outbreak would have serious economic effects. Depending on the regionalization scenario, returns to capital and management in the poultry meat and egg sectors would fall between $602 million and $853 million dollars over 16 quarters. Consumers of poultry meat lose $900 million in consumer surplus in the first four quarters, a decline of 10.7%. Egg consumer surplus falls 17.1%. Regionalization lowers the economic welfare losses for producers because it dampens the export loss.