The past decade has taught us that pathogenic microorganisms are adapting themselves to processing treatments and environmental conditions once thought to be effective in controlling their proliferation. Genetic exchange is sprouting new varieties of bacterial strains with increased abilities to cause disease. The scientific community must adopt a proactive approach, including an aggressive research agenda that seeks to determine the ecology of the food production and processing environments, as well as the basic biology of pathogenic organisms. In addition, it is crucial that we develop a well-integrated educational strategy that seeks to educate industry and consumers.