This paper presents an assessment of economic efficiency of different methods of reducing weed infestation in potato cultivation. Experimental objects included five weed control methods: mechanical as well as four objects of mechanical-chemical treatments with the use of herbicides and their mixtures - Command 480 EC, Command 480 EC + Afalon Dyspersyjny 450 SC, Stomp 400 SC, Stomp 400 SC + Afalon Dyspersyjny450 SC. On the mechanical-chemical treated objects, as compared with mechanical weeding, the obtained increase of market yield of tubers was 70,3-182,7 dt/ha. Orientation indexes of profitability (E1 and E2 ) indicate that chemical protection of the potato was profitable.