A menu-driven facility for complex sample size calculation in randomized controlled trials with a survival or a binary outcome

We present a menu-driven Stata program for the calculation of sample size or power for complex clinical trials with a survival time or a binary outcome. The features supported include up to six treatment arms, an arbitrary time-to-event distribution, fixed or time-varying hazard ratios, unequal patient allocation, loss to follow-up, staggered patient entry, and crossover of patients from their allocated treatment to an alternative treatment. The computations of sample size and power are based on the logrank test and are done according to the asymptotic distribution of the logrank test statistic, adjusted appropriately for the design features.


Issue Date:
2002
Publication Type:
Journal Article
DOI and Other Identifiers:
st0013 (Other)
PURL Identifier:
http://purl.umn.edu/115958
Published in:
Stata Journal, Volume 02, Number 2
Page range:
151-163
Total Pages:
13

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 Record created 2017-04-01, last modified 2017-08-16

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